197-205 JMB16-10055.fm

Cancer chemotherapy can be used depending on the cancer status either alone or in combination with surgery and/or radiotherapy. The effectiveness of chemotherapy in treatment of cancer patients is largely due to the cytostatic and cytotoxic effects of the drugs on tumor cells. Additionally, the cell cycle status of tumor cells is important in determining the effectiveness of chemotherapy because these agents are mainly active against proliferating Sor Mphase cells rather than resting (G 0 ) cells [1]. However, many chemotherapeutic drugs cannot distinguish proliferating normal cells from tumor cells, thereby causing damage to normal cells, which leads to side-effects. Several biochemical mechanisms have been implicated in chemotherapy-mediated tumor cell death, including apoptosis, necrosis, and autophagy [2-4]. However, the mechanism of this cell death requires further studies in Received: October 21, 2016 Accepted: October 31, 2016